Additional evidence of linkage between Crohn's disease and a putative locus on chromosome 12
نویسندگان
چکیده
منابع مشابه
Evidence for linkage between essential hypertension and a putative locus on human chromosome 17.
Several clinical and animal studies indicate that essential hypertension is inherited as a multifactorial trait with a significant genetic and environmental component. In the stroke-prone spontaneously hypertensive rat model, investigators have found evidence for linkage to blood pressure regulatory genes (quantitative trait loci) on rat chromosomes 2, 10, and X. In 1 human study of French and ...
متن کاملLinkage of Parkinson’s disease in two very early onset siblings to a locus on chromosome 1
Parkinson’s disease (PD) is a prevalent neurodegenerative disease that usually affects individuals over 50 years of age. Age at onset in a small subset of PD cases is considerably lower, and these are considered early-onset PD (EOPD) patients. Most PD cases appear sporadic, but approximately 15% are familial, and some of the familial cases exhibit Mendelian inheritance. Genetic analysis of fami...
متن کاملEvidence for an Alzheimer disease susceptibility locus on chromosome 12 and for further locus heterogeneity.
CONTEXT Alzheimer disease (AD) susceptibility genes have been identified on chromosomes 1, 14, 19, and 21, and a recent study has suggested a locus on chromosome 12. OBJECTIVE To confirm or refute the existence of a familial AD susceptibility locus on chromosome 12 in an independent sample of familial AD cases. DESIGN Retrospective cohort study. DNA data for 6 chromosome 12 genetic markers ...
متن کاملlinkage of parkinson’s disease in two very early onset siblings to a locus on chromosome 1
parkinson’s disease (pd) is a prevalent neurodegenerative disease that usually affects individuals over 50 years of age. age at onset in a small subset of pd cases is considerably lower, and these are considered early-onset pd (eopd) patients. most pd cases appear sporadic, but approximately 15% are familial, and some of the familial cases exhibit mendelian inheritance. genetic analysis of fami...
متن کاملEvidence for an inflammatory bowel disease locus on chromosome 3p26: linkage, transmission/disequilibrium and partitioning of linkage.
Crohn's disease and ulcerative colitis, the two major forms of idiopathic inflammatory bowel disease (IBD), are heritable, complex traits that appear to share some but not all susceptibility loci. We report that transmission/disequilibrium test analysis of a Crohn's disease genome scan dataset has detected an inflammatory bowel disease locus on chromosome 3p26 (nominal P=0.000052 and genome-wid...
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ژورنال
عنوان ژورنال: Genetics in Medicine
سال: 1999
ISSN: 1098-3600,1530-0366
DOI: 10.1097/00125817-199907000-00005